Neurobiology

Team Leader

Dr. Theodosis Kalamatianos

 

Clinical Studies

Neurobiological Research at the Department of Neurosurgery, University of Athens Medical School aims in the better understanding of the pathophysiologica mechanisms underlying neurological disease with the overarching goal to establish clinically relevant biomarkers and the development of novel/efficient therapies.

 

Clinical studies are carried out in collaboration with other departments of Evaggelismos Hospital, Athens Greece (Department of Biochemistry and Pathology) and focus on neurological disease of considerable neurosurgical interest, including normal pressure hydrocephalus, traumatic brain injury, subarachnoid hemorrhage and brain tumors.

 

Publications

Balaka C, Stranjalis G, Kalamatianos T, Koutsarnakis C, Bouras T, Boviatsis E, Sakas DE. Perioperative microdialysis in meningioma surgery: correlation of cerebral metabolites with clinical outcome. Acta Neurochir (Wien). 2014;156:2275-82.

 

Margetis K, Markianos M, Gatzonis S, Kalamatianos T, Sakas D. Orexin-a system neuromodulation by intrathecal baclofen. J Clin Psychopharmacol. 2014;34:535-7.

 

Margetis K, Markianos M, Gatzonis S, Kalamatianos T, Sakas D. Effects of intrathecal baclofen therapy on CSF neurotransmitter metabolite levels. J Clin Psychopharmacol. 2014;34:171-4.

 

Kalamatianos T, Markianos M, Margetis K, Bourlogiannis F, Stranjalis G. Higher Orexin A levels in lumbar compared to ventricular CSF: a study in idiopathic normal pressure hydrocephalus. Peptides. 2014;51:1-3.

 

Kalamatianos T, Stavrinou LC, Koutsarnakis C, Psachoulia C, Sakas DE, Stranjalis G. PlGF and sVEGFR-1 in chronic subdural hematoma: implications for hematoma development. J Neurosurg. 2013 Feb;118(2):353-7.

 

Stavrinou LC, Kalamatianos T, Stavrinou P, Papasilekas T, Psachoulia C, Tzavara C, Stranjalis G. Serum levels of S-100B after recreational scuba diving. Int J Sports Med. 2011 Dec;32(12):912-5

 

Preclinical Studies

Establishing animal models for the investigation of disease pathophysiology and the development of novel therapeutics in acute and chronic brain injury that results from traumatic/hemorrhagic injury or hydrocephalus remains one of the main goals of our departmental preclinical research.

 

Research on animal models of hydrocephalus and traumatic brain injury has thus far taken place at the Experimental Surgery Laboratory of Evaggelismos Hospita, Athens Greece. Studies include the analysis of brain injury at the tissue and cellular level (Figure 1) and its behavioral sequelae. The latter are investigated utilizing behavioral tests assessing learning and memory (Morris Water maze, Object Recognition), locomotor function, anxiety, depressive and species typical behavior (Open field, Elevated plus Maze, forced swim and marble burying tests).

 

Neurobiology

  

Figure 1. (Α-Β). Overt ventricular dilation (lateral and third ventricles, arrows) 4 weeks after intracisternal kaolin injection (B) in comparison to the normal ventricular system of rats (A) in an experimental model of chronic hydrocephalus. (C-D) Immature neurons (labeled by means of immunohistochemistry against doublecortin) within the mouse hippocampus 3 (C) and 14 days (D) after traumatic brain injury. Kalamatianos et al., unpublished observations.